Prof. Dr. Dr. Clemens Lange

Curriculum vitae

Prof. Dr. Dr. Clemens Lange, MD PhD




Ophtha-Lab, Department of Ophthalmology, St. Franziskus Hospital
Hohenzollernring 74
48145 Muenster, Germany

Professional experience

2022 - present:

Consultant, Department of Ophthalmology, St. Franziskus Hospital, Germany

2015 - 2021:

Consultant and head of the department for Inherited Retinal Disease, University Eye Hospital, Freiburg, Germany


Board Certification, German Board of Ophthalmology and Fellow of the European Board of Ophthalmology (FEBO)

2007 - 2014:

Residency, University Eye Hospital Freiburg, Germany

2009 - 2012:

Clinical research fellow, Moorfields Eye Hospital, Institute of Ophthalmology, Department of Genetics, London, UK

Academic and higher qualifications

2013 - present:

Group leader, Laboratory of Experimental Ophthalomology, University Eye Clinic Freiburg

2017 - 2021:

Principal Investigator, Sonderforschungsbereich, Neuromac SFB/TRR167 "Development, function and potential of myeloid cells in the central nervous system"


Professorship (Apl) in Ophthalmology, University of Freiburg

2009 - 2012:

PostDoc and Ph.D. studies, Institute of Ophthalmology, Moorfields Eye Hospital London, Prof. R. Ali and Prof. J. Bainbridge, UCL London, UK


MD degree, University Eye Clinic, Freiburg, grade “summa cum laude”


German Medical License Examination, University Freiburg, Germany
United States Medical Licence Examinations (USMLE), Germany

2003 - 2007:

Medical school, University of Freiburg, Germany
Clinical electives at University Eye Clinic Freiburg, Kantonsspital Zofingen, Switzerland and Memorial Sloan Kettering Cancer Center, New York, USA

Selected awards


Helmholtz Research Award of the German Society for Ophthalmology


Dr. Gaide AMD Research Award, The German Retina Society


Henning-Zügel-Stiftung Research Award, University of Freiburg


Moorfields Eye Hospital Research Medal, London, UK


UCL Post-Graduate Student Conference Grant, London, UK


NIHR Summer School Research Award, Ashridge, UK


Fleckenstein Young Researcher Award, University of Freiburg, Germany

Selected publications


Boneva SK, Wolf J, Rosmus DD, Schlecht A, Prinz G, Laich Y, Boeck M, Zhang P, Hilgendorf I, Stahl A, Reinhard T, Bainbridge J, Schlunck G, Agostini H, Wieghofer P, Lange CAK. Transcriptional Profiling Uncovers Human Hyalocytes as a Unique Innate Immune Cell Population. Front Immunol. 2020 Sep 11;11:567274. doi: 10.3389/fimmu.2020.567274. PMID: 33042148.


Wolf J, Auw-Haedrich C, Schlecht A, Boneva S, Mittelviefhaus H, Lapp T, Agostini H, Reinhard T, Schlunck G, Lange CAK. Transcriptional characterization of conjunctival melanoma identifies the cellular tumor microenvironment and prognostic gene signatures. Sci Rep. 2020 Oct 12;10(1):17022. doi: 10.1038/s41598-020-72864-0. PMID: 33046735.


Schlunck G, Boneva S, Wolf J, Schlecht A, Reinhard T, Auw-Hädrich C, Lange C. RNA Sequencing of Formalin-Fixed and Paraffin-Embedded Tissue as a Complementary Method in Ophthalmopathology. Klin Monbl Augenheilkd. 2020 Jul;237(7):860-866. English, German. doi: 10.1055/a-1187-1590. Epub 2020 Jul 13. PMID: 32659839.


Schlecht A, Boneva S, Gruber M, Zhang P, Horres R, Bucher F, Auw-Haedrich C, Hansen L, Stahl A, Hilgendorf I, Agostini H, Wieghofer P, Schlunck G, Wolf J*, Lange CAK*. Transcriptomic Characterization of Human Choroidal Neovascular Membranes Identifies Calprotectin as a Novel Biomarker for Patients with Age-Related Macular Degeneration. Am J Pathol. 2020 Aug;190(8):1632-1642. doi: 10.1016/j.ajpath.2020.04.004. Epub 2020 Apr 24. PMID: 32339498. * contributed equally as senior authors.


Lange C, Wolf J, Auw-Haedrich C, Schlecht A, Boneva S, Lapp T, Horres R, Agostini H, Martin G, Reinhard T, Schlunck G. Expression of the COVID-19 receptor ACE2 in the human conjunctiva. J Med Virol. 2020 May 6:10.1002/jmv.25981. doi: 10.1002/jmv.25981. Epub ahead of print. PMID: 32374427.


Boneva S, Schlecht A, Böhringer D, Mittelviefhaus H, Reinhard T, Agostini H, Auw-Haedrich C, Schlunck G, Wolf J*, Lange C*. 3' MACE RNA-sequencing allows for transcriptome profiling in human tissue samples after long-term storage. Lab Invest. 2020 May 28. doi: 10.1038/s41374-020-0446-z. Epub ahead of print. PMID: 32467590. * contributed equally as senior authors.


Boeck M, Thien A, Wolf J, Hagemeyer N, Laich Y, Yusuf D, Backofen R, Zhang P, Boneva S, Stahl A, Hilgendorf I, Agostini H, Prinz M, Wieghofer P, Schlunck G, Schlecht A, Lange C. Temporospatial distribution and transcriptional profile of retinal microglia in the oxygen-induced retinopathy mouse model. Glia. 2020 Sep;68(9):1859-1873. doi: 10.1002/glia.23810. Epub 2020 Mar 9. PMID: 32150307.


Lange CAK, Lehnert P, Boneva SK, Zhang P, Ludwig F, Boeker M, Hoffmeier K, Horres R, Schlunck G, Reinhard T, Böhringer D, Auw-Haedrich C. Increased expression of hypoxia-inducible factor-1 alpha and its impact on transcriptional changes and prognosis in malignant tumours of the ocular adnexa. Eye (Lond). 2018 Nov;32(11):1772-1782. doi: 10.1038/s41433-018-0172-6. Epub 2018 Jul 31. PMID: 30065361.


Lange C, Feltgen N, Junker B, Schulze-Bonsel K, Bach M. Resolving the clinical acuity categories "hand motion" and "counting fingers" using the Freiburg Visual Acuity Test (FrACT). Graefes Arch Clin Exp Ophthalmol. 2009 Jan;247(1):137-42. doi: 10.1007/s00417-008-0926-0. Epub 2008 Sep 3. PMID: 18766368.


Wang X, Abraham S, McKenzie JAG, Jeffs N, Swire M, Tripathi VB, Luhmann UFO, Lange CAK, Zhai Z, Arthur HM, Bainbridge J, Moss SE, Greenwood J. LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling. Nature. 2013 Jul 18;499(7458):306-11. doi: 10.1038/nature12345. PMID: 23868260.